Hi, I need help with essay on Antinuclear Antibodies (ANA) Test Results with Autoimmune Diseases. Paper must be at least 3750 words. Please, no plagiarized work!
The researcher states that the exact cause of autoimmune disorders is not clear though most of them have a genetic defect etiology. Antinuclear antibody (ANA) test is used to screen for the presence of autoimmune disorders in patients that have symptoms of an autoimmune reaction. ELISA, enzyme-linked immunoabsorbent assay and immunofluorescence microscopy are normally used to perform the test. This paper examines online and prints literature that discusses the use of antinuclear antibody tests in screening for autoimmune diseases. Bonaguri conducted a study describing joint laboratory clinics guideline for reducing clinically inappropriate requests for ANA tests in a broad geographical area for the diagnosis of autoimmune, the rheumatic disease. The researchers conducted an observational research that compared a number of ANA tests, anti-dsDNA, and anti-ENA, as well as positive test results before and after the establishment of the diagnostic algorithm in hospitalized patients. A joint guideline for autoantibody testing that placed ANA at the first level was in existence since January 2009. The researcher analyzed results that were carried in 2008 and 2009. The study’s result showed a significant reduction in the percentage of anti-dsDNA and anti-ENA tests. In addition, the study revealed an increase in the second level tests positivity of ENA and anti-dsDNA after the implementation of the protocol. The study is essential because it shades light on the topic under study by illustrating diagnostic protocols involved in ANA. Tonutti had a similar approach. Tonutti aimed at “evaluating the diagnostic accuracy of five commercially available enzyme immunoassay kits for ANA detection and to verify the possibility of using them as an alternative to the IIF method”. The study involved two groups. one group had participants without any autoimmune disease while the other group had patients with autoimmune disease. Sera have collected fro both groups, and ANA performed using IIF and the five enzyme assay kits. The results were varied.
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